Fischbach Group

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Friday, 10 July 2009 18:02 administrator
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  1. Walsh CT and Fischbach MA. Natural Products Version 2.0: Connecting Genes to Molecules. J Am Chem Soc 2010 Feb 1. doi:10.1021/ja909118a pmid:20121095. PubMed HubMed PubGet [Paper38]
  2. Dawlaty J, Zhang X, Fischbach MA, and Clardy J. Dapdiamides, Tripeptide Antibiotics Formed by Unconventional Amide Ligases (dagger). J Nat Prod 2009 Dec 30. doi:10.1021/np900685z pmid:20041689. PubMed HubMed PubGet [Paper37]
  3. Haas BJ, Kamoun S, Zody MC, Jiang RH, Handsaker RE, Cano LM, Grabherr M, Kodira CD, Raffaele S, Torto-Alalibo T, Bozkurt TO, Ah-Fong AM, Alvarado L, Anderson VL, Armstrong MR, Avrova A, Baxter L, Beynon J, Boevink PC, Bollmann SR, Bos JI, Bulone V, Cai G, Cakir C, Carrington JC, Chawner M, Conti L, Costanzo S, Ewan R, Fahlgren N, Fischbach MA, Fugelstad J, Gilroy EM, Gnerre S, Green PJ, Grenville-Briggs LJ, Griffith J, Gr?nwald NJ, Horn K, Horner NR, Hu CH, Huitema E, Jeong DH, Jones AM, Jones JD, Jones RW, Karlsson EK, Kunjeti SG, Lamour K, Liu Z, Ma L, Maclean D, Chibucos MC, McDonald H, McWalters J, Meijer HJ, Morgan W, Morris PF, Munro CA, O'Neill K, Ospina-Giraldo M, Pinz?n A, Pritchard L, Ramsahoye B, Ren Q, Restrepo S, Roy S, Sadanandom A, Savidor A, Schornack S, Schwartz DC, Schumann UD, Schwessinger B, Seyer L, Sharpe T, Silvar C, Song J, Studholme DJ, Sykes S, Thines M, van de Vondervoort PJ, Phuntumart V, Wawra S, Weide R, Win J, Young C, Zhou S, Fry W, Meyers BC, van West P, Ristaino J, Govers F, Birch PR, Whisson SC, Judelson HS, and Nusbaum C. Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans. Nature 2009 Sep 17; 461(7262) 393-8. doi:10.1038/nature08358 pmid:19741609. PubMed HubMed PubGet [Paper36]
  4. Fischbach MA and Walsh CT. Antibiotics for emerging pathogens. Science 2009 Aug 28; 325(5944) 1089-93. doi:10.1126/science.1176667 pmid:19713519. PubMed HubMed PubGet [Paper35]
  5. Fischbach MA. Antibiotics from microbes: converging to kill. Curr Opin Microbiol 2009 Oct; 12(5) 520-7. doi:10.1016/j.mib.2009.07.002 pmid:19695947. PubMed HubMed PubGet [Paper34]
  6. Walsh CT and Fischbach MA. New ways to squash superbugs. Sci Am 2009 Jul; 301(1) 44-51. pmid:19555023. PubMed HubMed PubGet [Paper33]
  7. Clardy J, Fischbach MA, and Currie CR. The natural history of antibiotics. Curr Biol 2009 Jun 9; 19(11) R437-41. doi:10.1016/j.cub.2009.04.001 pmid:19515346. PubMed HubMed PubGet [Paper32]
  8. Wieland Brown LC, Acker MG, Clardy J, Walsh CT, and Fischbach MA. Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin. Proc Natl Acad Sci U S A 2009 Feb 24; 106(8) 2549-53. doi:10.1073/pnas.0900008106 pmid:19196969. PubMed HubMed PubGet [Paper31]
  9. Walsh CT and Fischbach MA. Repurposing libraries of eukaryotic protein kinase inhibitors for antibiotic discovery. Proc Natl Acad Sci U S A 2009 Feb 10; 106(6) 1689-90. doi:10.1073/pnas.0813405106 pmid:19193851. PubMed HubMed PubGet [Paper30]
  10. L?pez D, Fischbach MA, Chu F, Losick R, and Kolter R. Structurally diverse natural products that cause potassium leakage trigger multicellularity in Bacillus subtilis. Proc Natl Acad Sci U S A 2009 Jan 6; 106(1) 280-5. doi:10.1073/pnas.0810940106 pmid:19114652. PubMed HubMed PubGet [Paper29]
  11. Sattely ES, Fischbach MA, and Walsh CT. Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways. Nat Prod Rep 2008 Aug; 25(4) 757-93. doi:10.1039/b801747f pmid:18663394. PubMed HubMed PubGet [Paper28]
  12. Stinear TP, Seemann T, Harrison PF, Jenkin GA, Davies JK, Johnson PD, Abdellah Z, Arrowsmith C, Chillingworth T, Churcher C, Clarke K, Cronin A, Davis P, Goodhead I, Holroyd N, Jagels K, Lord A, Moule S, Mungall K, Norbertczak H, Quail MA, Rabbinowitsch E, Walker D, White B, Whitehead S, Small PL, Brosch R, Ramakrishnan L, Fischbach MA, Parkhill J, and Cole ST. Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis. Genome Res 2008 May; 18(5) 729-41. doi:10.1101/gr.075069.107 pmid:18403782. PubMed HubMed PubGet [Paper27]
  13. Fischbach MA, Walsh CT, and Clardy J. The evolution of gene collectives: How natural selection drives chemical innovation. Proc Natl Acad Sci U S A 2008 Mar 25; 105(12) 4601-8. doi:10.1073/pnas.0709132105 pmid:18216259. PubMed HubMed PubGet [Paper26]
  14. Walsh CT and Fischbach MA. Inhibitors of sterol biosynthesis as Staphylococcus aureus antibiotics. Angew Chem Int Ed Engl 2008; 47(31) 5700-2. doi:10.1002/anie.200801801 pmid:18576462. PubMed HubMed PubGet [Paper25]
  15. Nolan EM, Fischbach MA, Koglin A, and Walsh CT. Biosynthetic tailoring of microcin E492m: post-translational modification affords an antibacterial siderophore-peptide conjugate. J Am Chem Soc 2007 Nov 21; 129(46) 14336-47. doi:10.1021/ja074650f pmid:17973380. PubMed HubMed PubGet [Paper24]
  16. Fischbach MA, Lai JR, Roche ED, Walsh CT, and Liu DR. Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes. Proc Natl Acad Sci U S A 2007 Jul 17; 104(29) 11951-6. doi:10.1073/pnas.0705348104 pmid:17620609. PubMed HubMed PubGet [Paper23]
  17. Fischbach MA and Clardy J. One pathway, many products. Nat Chem Biol 2007 Jul; 3(7) 353-5. doi:10.1038/nchembio0707-353 pmid:17576415. PubMed HubMed PubGet [Paper22]
  18. Butcher RA, Schroeder FC, Fischbach MA, Straight PD, Kolter R, Walsh CT, and Clardy J. The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis. Proc Natl Acad Sci U S A 2007 Jan 30; 104(5) 1506-9. doi:10.1073/pnas.0610503104 pmid:17234808. PubMed HubMed PubGet [Paper21]
  19. Straight PD, Fischbach MA, Walsh CT, Rudner DZ, and Kolter R. A singular enzymatic megacomplex from Bacillus subtilis. Proc Natl Acad Sci U S A 2007 Jan 2; 104(1) 305-10. doi:10.1073/pnas.0609073103 pmid:17190806. PubMed HubMed PubGet [Paper20]
  20. Clardy J, Fischbach MA, and Walsh CT. New antibiotics from bacterial natural products. Nat Biotechnol 2006 Dec; 24(12) 1541-50. doi:10.1038/nbt1266 pmid:17160060. PubMed HubMed PubGet [Paper19]
  21. Fischbach MA, Lin H, Zhou L, Yu Y, Abergel RJ, Liu DR, Raymond KN, Wanner BL, Strong RK, Walsh CT, Aderem A, and Smith KD. The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2. Proc Natl Acad Sci U S A 2006 Oct 31; 103(44) 16502-7. doi:10.1073/pnas.0604636103 pmid:17060628. PubMed HubMed PubGet [Paper18]
  22. Fischbach MA and Walsh CT. Biochemistry. Directing biosynthesis. Science 2006 Oct 27; 314(5799) 603-5. doi:10.1126/science.1132692 pmid:17068249. PubMed HubMed PubGet [Paper17]
  23. Lai JR, Fischbach MA, Liu DR, and Walsh CT. Localized protein interaction surfaces on the EntB carrier protein revealed by combinatorial mutagenesis and selection. J Am Chem Soc 2006 Aug 30; 128(34) 11002-3. doi:10.1021/ja063238h pmid:16925399. PubMed HubMed PubGet [Paper16]
  24. Larsen NA, Lin H, Wei R, Fischbach MA, and Walsh CT. Structural characterization of enterobactin hydrolase IroE. Biochemistry 2006 Aug 29; 45(34) 10184-90. doi:10.1021/bi060950i pmid:16922493. PubMed HubMed PubGet [Paper15]
  25. Jin M, Fischbach MA, and Clardy J. A biosynthetic gene cluster for the acetyl-CoA carboxylase inhibitor andrimid. J Am Chem Soc 2006 Aug 23; 128(33) 10660-1. doi:10.1021/ja063194c pmid:16910643. PubMed HubMed PubGet [Paper14]
  26. Fischbach MA and Walsh CT. Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms. Chem Rev 2006 Aug; 106(8) 3468-96. doi:10.1021/cr0503097 pmid:16895337. PubMed HubMed PubGet [Paper13]
  27. Lin H, Fischbach MA, Gatto GJ Jr, Liu DR, and Walsh CT. Bromoenterobactins as potent inhibitors of a pathogen-associated, siderophore-modifying C-glycosyltransferase. J Am Chem Soc 2006 Jul 26; 128(29) 9324-5. doi:10.1021/ja063236x pmid:16848455. PubMed HubMed PubGet [Paper12]
  28. Sharma SV, Fischbach MA, Haber DA, and Settleman J. "Oncogenic shock": explaining oncogene addiction through differential signal attenuation. Clin Cancer Res 2006 Jul 15; 12(14 Pt 2) 4392s-4395s. doi:10.1158/1078-0432.CCR-06-0096 pmid:16857816. PubMed HubMed PubGet [Paper11]
  29. Lai JR, Fischbach MA, Liu DR, and Walsh CT. A protein interaction surface in nonribosomal peptide synthesis mapped by combinatorial mutagenesis and selection. Proc Natl Acad Sci U S A 2006 Apr 4; 103(14) 5314-9. doi:10.1073/pnas.0601038103 pmid:16567620. PubMed HubMed PubGet [Paper10]
  30. Fischbach MA, Lin H, Liu DR, and Walsh CT. How pathogenic bacteria evade mammalian sabotage in the battle for iron. Nat Chem Biol 2006 Mar; 2(3) 132-8. doi:10.1038/nchembio771 pmid:16485005. PubMed HubMed PubGet [Paper9]
  31. Luo M, Lin H, Fischbach MA, Liu DR, Walsh CT, and Groves JT. Enzymatic tailoring of enterobactin alters membrane partitioning and iron acquisition. ACS Chem Biol 2006 Feb 17; 1(1) 29-32. doi:10.1021/cb0500034 pmid:17163637. PubMed HubMed PubGet [Paper8]
  32. Dorrestein PC, Blackhall J, Straight PD, Fischbach MA, Garneau-Tsodikova S, Edwards DJ, McLaughlin S, Lin M, Gerwick WH, Kolter R, Walsh CT, and Kelleher NL. Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry. Biochemistry 2006 Feb 14; 45(6) 1537-46. doi:10.1021/bi052333k pmid:16460000. PubMed HubMed PubGet [Paper7]
  33. Garstecki P, J Fuerstman M, Fischbach MA, Sia SK, and Whitesides GM. Mixing with bubbles: a practical technology for use with portable microfluidic devices. Lab Chip 2006 Feb; 6(2) 207-12. doi:10.1039/b510843h pmid:16450029. PubMed HubMed PubGet [Paper6]
  34. Fischbach MA and Settleman J. Regulation of the nucleotide state of oncogenic ras proteins by nucleoside diphosphate kinase. Methods Enzymol 2006; 407 33-45. doi:10.1016/S0076-6879(05)07004-7 pmid:16757312. PubMed HubMed PubGet [Paper5]
  35. Lin H, Fischbach MA, Liu DR, and Walsh CT. In vitro characterization of salmochelin and enterobactin trilactone hydrolases IroD, IroE, and Fes. J Am Chem Soc 2005 Aug 10; 127(31) 11075-84. doi:10.1021/ja0522027 pmid:16076215. PubMed HubMed PubGet [Paper4]
  36. Fischbach MA, Lin H, Liu DR, and Walsh CT. In vitro characterization of IroB, a pathogen-associated C-glycosyltransferase. Proc Natl Acad Sci U S A 2005 Jan 18; 102(3) 571-6. doi:10.1073/pnas.0408463102 pmid:15598734. PubMed HubMed PubGet [Paper3]
  37. Wolfe DB, Conroy RS, Garstecki P, Mayers BT, Fischbach MA, Paul KE, Prentiss M, and Whitesides GM. Dynamic control of liquid-core/liquid-cladding optical waveguides. Proc Natl Acad Sci U S A 2004 Aug 24; 101(34) 12434-8. doi:10.1073/pnas.0404423101 pmid:15314232. PubMed HubMed PubGet [Paper2]
  38. Fischbach MA and Settleman J. Specific biochemical inactivation of oncogenic Ras proteins by nucleoside diphosphate kinase. Cancer Res 2003 Jul 15; 63(14) 4089-94. pmid:12874011. PubMed HubMed PubGet [Paper1]